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Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling
BACKGROUND: Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of the renin–angiotensin system (RAS) contributes to increase cell stress, while RAS...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092859/ https://www.ncbi.nlm.nih.gov/pubmed/30134927 http://dx.doi.org/10.1186/s10020-018-0044-3 |