Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains

C57BL/6N (N) and C57BL/6J (J) mice possess key genetic differences, including a deletion in the Nicotinamide nucleotide transhydrogenase (Nnt) gene that results in a non-functional protein in J mice. NNT regulates mitochondrial oxidative stress. Although elevated oxidative stress can compromise hema...

Descripción completa

Detalles Bibliográficos
Autores principales: Morales-Hernández, Antonio, Martinat, Alice, Chabot, Ashley, Kang, Guolian, McKinney-Freeman, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093083/
https://www.ncbi.nlm.nih.gov/pubmed/30017822
http://dx.doi.org/10.1016/j.stemcr.2018.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093083/
https://www.ncbi.nlm.nih.gov/pubmed/30017822
http://dx.doi.org/10.1016/j.stemcr.2018.06.011

Ejemplares similares