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Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains
C57BL/6N (N) and C57BL/6J (J) mice possess key genetic differences, including a deletion in the Nicotinamide nucleotide transhydrogenase (Nnt) gene that results in a non-functional protein in J mice. NNT regulates mitochondrial oxidative stress. Although elevated oxidative stress can compromise hema...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093083/ https://www.ncbi.nlm.nih.gov/pubmed/30017822 http://dx.doi.org/10.1016/j.stemcr.2018.06.011 |