Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells

The PD-1 pathway, consisting of the co-inhibitory receptor PD-1 on T cells and its ligand (PD-L1) on antigen-presenting cells (APCs), is a major mechanism of tumor immune evasion. PD-1 and PD-L1 blockade antibodies have produced remarkable clinical activities against a subset of cancers. Binding bet...

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Detalles Bibliográficos
Autores principales: Zhao, Yunlong, Harrison, Devin L., Song, Yuran, Ji, Jie, Huang, Jun, Hui, Enfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093302/
https://www.ncbi.nlm.nih.gov/pubmed/29996099
http://dx.doi.org/10.1016/j.celrep.2018.06.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093302/
https://www.ncbi.nlm.nih.gov/pubmed/29996099
http://dx.doi.org/10.1016/j.celrep.2018.06.054

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