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Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

Voltage-activated potassium (Kv) channels open to conduct K(+) ions in response to membrane depolarization, and subsequently enter non-conducting states through distinct mechanisms of inactivation. X-ray structures of detergent-solubilized Kv channels appear to have captured an open state even thoug...

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Detalles Bibliográficos
Autores principales: Matthies, Doreen, Bae, Chanhyung, Toombes, Gilman ES, Fox, Tara, Bartesaghi, Alberto, Subramaniam, Sriram, Swartz, Kenton Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093707/
https://www.ncbi.nlm.nih.gov/pubmed/30109985
http://dx.doi.org/10.7554/eLife.37558