Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different channels within the family despite their high sequence and structure homology. The molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Rheinberger, Jan, Gao, Xiaolong, Schmidpeter, Philipp AM, Nimigean, Crina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093708/
https://www.ncbi.nlm.nih.gov/pubmed/30028291
http://dx.doi.org/10.7554/eLife.39775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093708/
https://www.ncbi.nlm.nih.gov/pubmed/30028291
http://dx.doi.org/10.7554/eLife.39775

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