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Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different channels within the family despite their high sequence and structure homology. The molecular mechanisms...

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Detalles Bibliográficos
Autores principales:	Rheinberger, Jan, Gao, Xiaolong, Schmidpeter, Philipp AM, Nimigean, Crina M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093708/ https://www.ncbi.nlm.nih.gov/pubmed/30028291 http://dx.doi.org/10.7554/eLife.39775

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