Fluorescence detection of DNA mismatch repair in human cells

Mismatched base pairs, produced by nucleotide misincorporation by DNA polymerase, are repaired by the mismatch repair (MMR) pathway to maintain genetic integrity. We have developed a method for the fluorescence detection of the cellular MMR ability. A mismatch, which would generate a stop codon in t...

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Detalles Bibliográficos
Autores principales: Ito, Shunsuke, Shiraishi, Miyako, Tsuchihashi, Kazuki, Takatsuka, Reine, Yamamoto, Junpei, Kuraoka, Isao, Iwai, Shigenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093906/
https://www.ncbi.nlm.nih.gov/pubmed/30111891
http://dx.doi.org/10.1038/s41598-018-30733-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093906/
https://www.ncbi.nlm.nih.gov/pubmed/30111891
http://dx.doi.org/10.1038/s41598-018-30733-x

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