Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling

Ecdysone is an arthropod molting hormone and has been marketed as a non-androgenic natural anabolic and adaptogen. However, the safety profile of ecdysone is largely undetermined. After ecdysone treatment for 2 weeks, mice developed albuminuria with histologic signs of glomerular injury, including h...

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Detalles Bibliográficos
Autores principales: Lu, Minglei, Wang, Pei, Ge, Yan, Dworkin, Lance, Brem, Andrew, Liu, Zhangsuo, Gong, Rujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093907/
https://www.ncbi.nlm.nih.gov/pubmed/30111886
http://dx.doi.org/10.1038/s41598-018-29483-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093907/
https://www.ncbi.nlm.nih.gov/pubmed/30111886
http://dx.doi.org/10.1038/s41598-018-29483-7

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