Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Primary effusion lymphoma (PEL) is caused by Kaposi’s sarcoma-associated herpesvirus. Our understanding of PEL is poor and therefore treatment strategies are lacking. To address this need, we conducted genome-wide CRISPR/Cas9 knockout screens in eight PEL cell lines. Integration with data from unrel...

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Detalles Bibliográficos
Autores principales: Manzano, Mark, Patil, Ajinkya, Waldrop, Alexander, Dave, Sandeep S., Behdad, Amir, Gottwein, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093911/
https://www.ncbi.nlm.nih.gov/pubmed/30111820
http://dx.doi.org/10.1038/s41467-018-05506-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093911/
https://www.ncbi.nlm.nih.gov/pubmed/30111820
http://dx.doi.org/10.1038/s41467-018-05506-9

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