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The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila

Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Droso...

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Detalles Bibliográficos
Autores principales: Vaughan, Leigh, Marley, Richard, Miellet, Sara, Hartley, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094046/
https://www.ncbi.nlm.nih.gov/pubmed/29032244
http://dx.doi.org/10.1016/j.exger.2017.10.011