O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1

Cancer cells often heavily depend on the ubiquitin-proteasome system (UPS) for their growth and survival. Irrespective of their strong dependence on the proteasome activity, cancer cells, except for multiple myeloma, are mostly resistant to proteasome inhibitors. A major cause of this resistance is...

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Detalles Bibliográficos
Autores principales: Sekine, Hiroki, Okazaki, Keito, Kato, Koichiro, Alam, M. Morshedul, Shima, Hiroki, Katsuoka, Fumiki, Tsujita, Tadayuki, Suzuki, Norio, Kobayashi, Akira, Igarashi, Kazuhiko, Yamamoto, Masayuki, Motohashi, Hozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094050/
https://www.ncbi.nlm.nih.gov/pubmed/29941490
http://dx.doi.org/10.1128/MCB.00252-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094050/
https://www.ncbi.nlm.nih.gov/pubmed/29941490
http://dx.doi.org/10.1128/MCB.00252-18

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