Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

Curcumin, the active ingredient in Curcuma longa, has been in medicinal use since ancient times. However, the therapeutic targets and signaling cascades modulated by curcumin have been enigmatic despite extensive research. Here we identify dual-specificity tyrosine-regulated kinase 2 (DYRK2), a posi...

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Detalles Bibliográficos
Autores principales: Banerjee, Sourav, Ji, Chenggong, Mayfield, Joshua E., Goel, Apollina, Xiao, Junyu, Dixon, Jack E., Guo, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094102/
https://www.ncbi.nlm.nih.gov/pubmed/29987021
http://dx.doi.org/10.1073/pnas.1806797115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094102/
https://www.ncbi.nlm.nih.gov/pubmed/29987021
http://dx.doi.org/10.1073/pnas.1806797115

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