Elesclomol restores mitochondrial function in genetic models of copper deficiency

Copper is an essential cofactor of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Inherited loss-of-function mutations in several genes encoding proteins required for copper delivery to CcO result in diminished CcO activity and severe pathologic conditions in...

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Detalles Bibliográficos
Autores principales: Soma, Shivatheja, Latimer, Andrew J., Chun, Haarin, Vicary, Alison C., Timbalia, Shrishiv A., Boulet, Aren, Rahn, Jennifer J., Chan, Sherine S. L., Leary, Scot C., Kim, Byung-Eun, Gitlin, Jonathan D., Gohil, Vishal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094114/
https://www.ncbi.nlm.nih.gov/pubmed/30038027
http://dx.doi.org/10.1073/pnas.1806296115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094114/
https://www.ncbi.nlm.nih.gov/pubmed/30038027
http://dx.doi.org/10.1073/pnas.1806296115

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