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Elesclomol restores mitochondrial function in genetic models of copper deficiency

Copper is an essential cofactor of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Inherited loss-of-function mutations in several genes encoding proteins required for copper delivery to CcO result in diminished CcO activity and severe pathologic conditions in...

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Detalles Bibliográficos
Autores principales:	Soma, Shivatheja, Latimer, Andrew J., Chun, Haarin, Vicary, Alison C., Timbalia, Shrishiv A., Boulet, Aren, Rahn, Jennifer J., Chan, Sherine S. L., Leary, Scot C., Kim, Byung-Eun, Gitlin, Jonathan D., Gohil, Vishal M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094114/ https://www.ncbi.nlm.nih.gov/pubmed/30038027 http://dx.doi.org/10.1073/pnas.1806296115

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