Recombinant Listeria promotes tumor rejection by CD8(+) T cell-dependent remodeling of the tumor microenvironment

Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria monocytogenes expressing tumor antigens (LADD-Ag) in...

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Detalles Bibliográficos
Autores principales: Deng, Weiwen, Lira, Victor, Hudson, Thomas E., Lemmens, Edward E., Hanson, William G., Flores, Ruben, Barajas, Gonzalo, Katibah, George E., Desbien, Anthony L., Lauer, Peter, Leong, Meredith L., Portnoy, Daniel A., Dubensky, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094133/
https://www.ncbi.nlm.nih.gov/pubmed/30038013
http://dx.doi.org/10.1073/pnas.1801910115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094133/
https://www.ncbi.nlm.nih.gov/pubmed/30038013
http://dx.doi.org/10.1073/pnas.1801910115

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