Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic islets of Langerhans. In β-cells it transports zinc into insulin-containing secretory granules. Loss-of-function (LOF) mutations in SLC30A8 protect against type 2 diabetes in humans. In this study, we generated a knocki...

Descripción completa

Detalles Bibliográficos
Autores principales: Kleiner, Sandra, Gomez, Daniel, Megra, Bezawit, Na, Erqian, Bhavsar, Ramandeep, Cavino, Katie, Xin, Yurong, Rojas, Jose, Dominguez-Gutierrez, Giselle, Zambrowicz, Brian, Carrat, Gaelle, Chabosseau, Pauline, Hu, Ming, Murphy, Andrew J., Yancopoulos, George D., Rutter, Guy A., Gromada, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094147/
https://www.ncbi.nlm.nih.gov/pubmed/30038024
http://dx.doi.org/10.1073/pnas.1721418115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094147/
https://www.ncbi.nlm.nih.gov/pubmed/30038024
http://dx.doi.org/10.1073/pnas.1721418115

Ejemplares similares