Design, Synthesis and Evaluation of Substituted Aryl-2-Nitrovinyl Derivatives as Small Molecules Proteasome Inhibitors

Based on the existing structure activity relationship for proteasome inhibitors, a number of substituted aryl-2-nitrovinyl derivatives have been synthesized as Michael acceptor and their cytotoxicity and proteasome inhibitory effects were evaluated on two cancer cell lines. Compound 2d exhibited IC(...

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Detalles Bibliográficos
Autores principales: Faghih Akhlaghi, Masoud, Daeihamed, Marjan, Ayatollahi, Seyed Abdolmajid, Kobarfard, Farzad, Ata, Athar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094432/
https://www.ncbi.nlm.nih.gov/pubmed/30127814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094432/
https://www.ncbi.nlm.nih.gov/pubmed/30127814

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