Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents

A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4)...

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Detalles Bibliográficos
Autores principales: Faghih-Mirzaei, Ehsan, Seifi, Mohammad, Abaszadeh, Mehdi, Zomorodian, Kamiar, Helali, Helia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094435/
https://www.ncbi.nlm.nih.gov/pubmed/30127812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094435/
https://www.ncbi.nlm.nih.gov/pubmed/30127812

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