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First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications

BACKGROUND: The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several typical malignancies. Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the genetic land...

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Detalles Bibliográficos
Autores principales: Löffler, Markus W., Steinhilber, Julia, Hilke, Franz J., Haen, Sebastian P., Bösmüller, Hans, Montes-Mojarro, Ivonne-Aidee, Bonzheim, Irina, Stäbler, Antje, Faust, Ulrike, Grasshoff, Ute, Königsrainer, Ingmar, Rammensee, Hans-Georg, Kanz, Lothar, Königsrainer, Alfred, Beckert, Stefan, Riess, Olaf, Schroeder, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094911/
https://www.ncbi.nlm.nih.gov/pubmed/30111295
http://dx.doi.org/10.1186/s12881-018-0651-4