Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty

Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)—phylogenetic inference of ancestral sequences followed by synthesis and experimental characterization. Usually, some sequence sites are amb...

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Detalles Bibliográficos
Autores principales: Eick, Geeta N., Bridgham, Jamie T., Anderson, Douglas P., Harms, Michael J., Thornton, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Molecular Biology and Evolution 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095102/
https://www.ncbi.nlm.nih.gov/pubmed/27795231
http://dx.doi.org/10.1093/molbev/msw223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095102/
https://www.ncbi.nlm.nih.gov/pubmed/27795231
http://dx.doi.org/10.1093/molbev/msw223

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