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Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty
Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)—phylogenetic inference of ancestral sequences followed by synthesis and experimental characterization. Usually, some sequence sites are amb...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society for Molecular Biology and Evolution
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095102/ https://www.ncbi.nlm.nih.gov/pubmed/27795231 http://dx.doi.org/10.1093/molbev/msw223 |