CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

Protein phosphatase 2A (PP2A) inhibition causes hy-perphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear. We demonstrate that Cancerous Inhibitor of PP2A (CIP2A), an endogenous PP2A inhibitor,...

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Detalles Bibliográficos
Autores principales: Shentu, Yang-Ping, Huo, Yuda, Feng, Xiao-Long, Gilbert, James, Zhang, Qing, Liuyang, Zhen-Yu, Wang, Xiu-Lian, Wang, Guan, Zhou, Huan, Wang, Xiao-Chuan, Wang, Jian-Zhi, Lu, You-Ming, Westermarck, Jukka, Man, Heng-Ye, Liu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095478/
https://www.ncbi.nlm.nih.gov/pubmed/30021167
http://dx.doi.org/10.1016/j.celrep.2018.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095478/
https://www.ncbi.nlm.nih.gov/pubmed/30021167
http://dx.doi.org/10.1016/j.celrep.2018.06.009

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