AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer

Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as “telomere syndromes”, which are provoked by extrem...

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Detalles Bibliográficos
Autores principales: Muñoz-Lorente, Miguel A., Martínez, Paula, Tejera, Águeda, Whittemore, Kurt, Moisés-Silva, Ana Carolina, Bosch, Fàtima, Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095492/
https://www.ncbi.nlm.nih.gov/pubmed/30114189
http://dx.doi.org/10.1371/journal.pgen.1007562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095492/
https://www.ncbi.nlm.nih.gov/pubmed/30114189
http://dx.doi.org/10.1371/journal.pgen.1007562

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