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Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins
It is well accepted that the introduction of negative supercoils locally unwinds the DNA double helix, influencing thus the activity of proteins. Despite the use of recent methods of molecular dynamics simulations to model the DNA supercoiling-induced DNA deformation, the precise extent and location...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095550/ https://www.ncbi.nlm.nih.gov/pubmed/30114256 http://dx.doi.org/10.1371/journal.pone.0202138 |