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Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast
Cell size scales with ploidy in a great range of eukaryotes, but the underlying mechanisms remain unknown. Using various orthogonal single-cell approaches, we show that cell size increases linearly with centromere (CEN) copy number in budding yeast. This effect is due to a G1 delay mediated by incre...
Autores principales: | Martínez-Láinez, Joan M., Moreno, David F., Parisi, Eva, Clotet, Josep, Aldea, Martí |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095599/ https://www.ncbi.nlm.nih.gov/pubmed/30080861 http://dx.doi.org/10.1371/journal.pbio.2005388 |
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