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Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone

Pontine noradrenergic neurones form part of a descending inhibitory system that influences spinal nociceptive processing. Weak or absent descending inhibition is a common feature of chronic pain patients. We examined the extent to which the descending noradrenergic system is tonically active, how co...

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Detalles Bibliográficos
Autores principales: Patel, Ryan, Qu, Chaoling, Xie, Jennifer Y., Porreca, Frank, Dickenson, Anthony H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095727/
https://www.ncbi.nlm.nih.gov/pubmed/29863529
http://dx.doi.org/10.1097/j.pain.0000000000001300