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Insight into the molecular mechanism behind PEG-mediated stabilization of biofluid lipases
Bioconjugates established between anionic polyethylene glycol (PEG) based polymers and cationic proteins have proven to be a promising strategy to engineer thermostable biocatalysts. However, the enzyme activity of these bioconjugates is very low and the mechanism of non-covalent PEG-stabilization i...
Autores principales: | Pérez, Bianca, Coletta, Andrea, Pedersen, Jannik N., Petersen, Steen V., Periole, Xavier, Pedersen, Jan Skov, Sessions, Richard B., Guo, Zheng, Perriman, Adam, Schiøtt, Birgit |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095910/ https://www.ncbi.nlm.nih.gov/pubmed/30115948 http://dx.doi.org/10.1038/s41598-018-29871-z |
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