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Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

The Adverse Outcome Pathways (AOPs) are designed to provide mechanistic understanding of complex biological systems and pathways of toxicity that result in adverse outcomes (AOs) relevant to regulatory endpoints. AOP concept captures in a structured way the causal relationships resulting from initia...

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Detalles Bibliográficos
Autores principales: Sachana, Magdalini, Rolaki, Alexandra, Bal-Price, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095943/
https://www.ncbi.nlm.nih.gov/pubmed/29524501
http://dx.doi.org/10.1016/j.taap.2018.02.024