Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice

Rationale: Successful treatment of pancreatic cancer remains a challenge due to desmoplasia and prevalence of KRAS mutation. While hedgehog (Hh) ligand levels are upregulated in pancreatic cancer cells and contribute to desmoplasia, there is significant downregulation of tumor suppressor let-7b, whi...

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Detalles Bibliográficos
Autores principales: Kumar, Virender, Mundra, Vaibhav, Peng, Yang, Wang, Yingzhe, Tan, Chalet, Mahato, Ram I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096395/
https://www.ncbi.nlm.nih.gov/pubmed/30128034
http://dx.doi.org/10.7150/thno.24945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096395/
https://www.ncbi.nlm.nih.gov/pubmed/30128034
http://dx.doi.org/10.7150/thno.24945

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