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Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice
Rationale: Successful treatment of pancreatic cancer remains a challenge due to desmoplasia and prevalence of KRAS mutation. While hedgehog (Hh) ligand levels are upregulated in pancreatic cancer cells and contribute to desmoplasia, there is significant downregulation of tumor suppressor let-7b, whi...
Autores principales: | Kumar, Virender, Mundra, Vaibhav, Peng, Yang, Wang, Yingzhe, Tan, Chalet, Mahato, Ram I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096395/ https://www.ncbi.nlm.nih.gov/pubmed/30128034 http://dx.doi.org/10.7150/thno.24945 |
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