Cargando…

Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice

AIMS/HYPOTHESIS: Islet transplantation is a treatment option that can help individuals with type 1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can hamper islet survival and engraftment due to the size of the islets and loss of the native microvasculature. We hyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Yang, Gamble, Anissa, Pawlick, Rena, Pepper, Andrew R., Salama, Bassem, Toms, Derek, Razian, Golsa, Ellis, Cara, Bruni, Antonio, Gala-Lopez, Boris, Lu, Jia (Lulu), Vovko, Heather, Chiu, Cecilia, Abdo, Shaaban, Kin, Tatsuya, Korbutt, Greg, Shapiro, A. M. James, Ungrin, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096633/ https://www.ncbi.nlm.nih.gov/pubmed/29971529 http://dx.doi.org/10.1007/s00125-018-4672-5

Ejemplares similares

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
por: Razian, Golsa, et al.
Publicado: (2013)

Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells
por: Gamble, Anissa, et al.
Publicado: (2018)

Ferroptosis-inducing agents compromise in vitro human islet viability and function
por: Bruni, Antonio, et al.
Publicado: (2018)

Restoring normoglycaemia: not so harmless
por: Preiser, Jean-Charles
Publicado: (2008)

Should strict normoglycaemia be maintained in critically ill children?
por: Markhorst, Dick G., et al.
Publicado: (2008)

A Simple and Low-Cost Monitoring System to Investigate Environmental Conditions in a Biological Research Laboratory
por: Gurdita, Akshay, et al.
Publicado: (2016)

Production, Characterization, and Function of Pseudoislets from Perinatal Canine Pancreas
por: Czernichow, P., et al.
Publicado: (2019)

In Vitro Formation of β Cell Pseudoislets Using Islet-Derived Endothelial Cells
por: Spelios, Michael G., et al.
Publicado: (2013)

Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets
por: Lorza-Gil, Estela, et al.
Publicado: (2019)

The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets
por: Wieland, Fredrik C., et al.
Publicado: (2021)

Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia
por: de Abreu, L., et al.
Publicado: (2015)

Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia
por: Gaffney, Christopher J., et al.
Publicado: (2017)

Incorporation of Bone Marrow Cells in Pancreatic Pseudoislets Improves Posttransplant Vascularization and Endocrine Function
por: Wittig, Christine, et al.
Publicado: (2013)

Methodological approaches in aggregate formation and microscopic analysis to assess pseudoislet morphology and cellular interactions
por: Wieland, Fredrik, et al.
Publicado: (2022)

Reversion from prediabetes to normoglycaemia and risk of cardiovascular disease and mortality: the Whitehall II cohort study
por: Vistisen, Dorte, et al.
Publicado: (2019)

Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes
por: Ziegler, Dan, et al.
Publicado: (2015)

Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
por: Hilderink, Janneke, et al.
Publicado: (2015)

Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device
por: Pepper, Andrew R., et al.
Publicado: (2015)

Lung-Derived Microscaffolds Facilitate Diabetes Reversal after Mouse and Human Intraperitoneal Islet Transplantation
por: Abualhassan, Nasser, et al.
Publicado: (2016)

Simulated Cholinergic Reinnervation of β (INS-1) Cells: Antidiabetic Utility of Heterotypic Pseudoislets Containing β Cell and Cholinergic Cell
por: Jiao, Ao, et al.
Publicado: (2018)

Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production
por: Cornell, Deborah, et al.
Publicado: (2022)

Efficacy and safety of alirocumab in people with prediabetes vs those with normoglycaemia at baseline: a pooled analysis of 10 phase III ODYSSEY clinical trials
por: Leiter, L. A., et al.
Publicado: (2017)

Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice
por: Green, Alastair D, et al.
Publicado: (2016)

Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues
por: Teraoku, Hiroki, et al.
Publicado: (2017)

The 30-year cardiovascular risk profile of South Africans with diagnosed diabetes, undiagnosed diabetes, pre-diabetes or normoglycaemia: the Bellville, South Africa pilot study
por: Matsha, Tandi E, et al.
Publicado: (2012)

Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China
por: Wu, Shuolin, et al.
Publicado: (2017)

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
por: Pepper, Andrew R., et al.
Publicado: (2017)

Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets
por: Harata, Mikako, et al.
Publicado: (2018)

FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
por: Lorza-Gil, Estela, et al.
Publicado: (2020)

Comparison of incidence, rate and length of all-cause hospital admissions between adults with normoglycaemia, impaired fasting glucose and diabetes: a retrospective cohort study in Geelong, Australia
por: Sajjad, Muhammad Amber, et al.
Publicado: (2018)

Handbook of Bioengineering
por: Newhouse, Kenneth E.
Publicado: (1987)

Bioengineering of the Uterus
por: Yoshimasa, Yushi, et al.
Publicado: (2021)

An Argument in Favour of Tobacco
Publicado: (1893)

Emerging areas in bioengineering
por: Chang, Ho-nam
Publicado: (2018)

Bioengineering Aspects of the Lung
por: Reynolds, Herbert Y.
Publicado: (1978)

Bioengineering and the cardiovascular system
por: Nerem, Robert M
Publicado: (2013)

Bioengineering Liver Transplantation
por: Verstegen, Monique M.A., et al.
Publicado: (2019)

Tricin Biosynthesis and Bioengineering
por: Lam, Pui Ying, et al.
Publicado: (2021)

Weapons abandoned in favour of detectors
Publicado: (2000)

Experimentally favoured potential for mesons
por: Olivier, D
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_hl7tiv9vrq8phphsmvq8kun93i