Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

Herein we report the preparation of ammonium [(11)C]thiocyanate via the reaction of [(11)C]CS(2) with ammonia. The [(11)C]SCN(–) ion is demonstrated as a potent nucleophile that can be used to readily generate a range of (11)C-labelled thiocyanate molecules in high conversions. Furthermore, novel (1...

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Detalles Bibliográficos
Autores principales: Haywood, Tom, Cesarec, Sara, Kealey, Steven, Plisson, Christophe, Miller, Philip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096773/
https://www.ncbi.nlm.nih.gov/pubmed/30151085
http://dx.doi.org/10.1039/c7md00425g
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author Haywood, Tom
Cesarec, Sara
Kealey, Steven
Plisson, Christophe
Miller, Philip W.
author_facet Haywood, Tom
Cesarec, Sara
Kealey, Steven
Plisson, Christophe
Miller, Philip W.
author_sort Haywood, Tom
collection PubMed
description Herein we report the preparation of ammonium [(11)C]thiocyanate via the reaction of [(11)C]CS(2) with ammonia. The [(11)C]SCN(–) ion is demonstrated as a potent nucleophile that can be used to readily generate a range of (11)C-labelled thiocyanate molecules in high conversions. Furthermore, novel (11)C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction.
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spelling pubmed-60967732019-07-02 Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling Haywood, Tom Cesarec, Sara Kealey, Steven Plisson, Christophe Miller, Philip W. Medchemcomm Chemistry Herein we report the preparation of ammonium [(11)C]thiocyanate via the reaction of [(11)C]CS(2) with ammonia. The [(11)C]SCN(–) ion is demonstrated as a potent nucleophile that can be used to readily generate a range of (11)C-labelled thiocyanate molecules in high conversions. Furthermore, novel (11)C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction. Royal Society of Chemistry 2018-07-02 /pmc/articles/PMC6096773/ /pubmed/30151085 http://dx.doi.org/10.1039/c7md00425g Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Haywood, Tom
Cesarec, Sara
Kealey, Steven
Plisson, Christophe
Miller, Philip W.
Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title_full Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title_fullStr Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title_full_unstemmed Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title_short Ammonium [(11)C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
title_sort ammonium [(11)c]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096773/
https://www.ncbi.nlm.nih.gov/pubmed/30151085
http://dx.doi.org/10.1039/c7md00425g
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