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Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

PURPOSE OF REVIEW: The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. For Alzheimer’s disease (AD), more than 20 risk loci have been identified. However, we are now facing three new challenges:...

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Detalles Bibliográficos
Autores principales: Dourlen, Pierre, Chapuis, Julien, Lambert, Jean-Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096908/
https://www.ncbi.nlm.nih.gov/pubmed/30147999
http://dx.doi.org/10.1007/s40142-018-0141-1