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Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals
PURPOSE OF REVIEW: The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. For Alzheimer’s disease (AD), more than 20 risk loci have been identified. However, we are now facing three new challenges:...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096908/ https://www.ncbi.nlm.nih.gov/pubmed/30147999 http://dx.doi.org/10.1007/s40142-018-0141-1 |