Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed. Germline mutations in the BRCA 1/2 genes are the m...

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Detalles Bibliográficos
Autores principales: da Cunha Colombo Bonadio, Renata Rodrigues, Fogace, Rodrigo Nogueira, Miranda, Vanessa Costa, Diz, Maria del Pilar Estevez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096977/
https://www.ncbi.nlm.nih.gov/pubmed/30133561
http://dx.doi.org/10.6061/clinics/2018/e450s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096977/
https://www.ncbi.nlm.nih.gov/pubmed/30133561
http://dx.doi.org/10.6061/clinics/2018/e450s

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