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Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

BACKGROUND: Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead to disease-specific PTMs detectable in the c...

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Detalles Bibliográficos
Autores principales: Bäckryd, Emmanuel, Edström, Sofia, Gerdle, Björn, Ghafouri, Bijar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097305/
https://www.ncbi.nlm.nih.gov/pubmed/30115020
http://dx.doi.org/10.1186/s12883-018-1116-2