Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells

Pancreatic cancer (PC) is highly resistant to current therapies; thus, there is an urgent need to develop new treatment strategies. The proteasome is crucially important for proteostasis, which is involved in cell proliferation and survival, making it an attractive therapeutic target in cancer. Howe...

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Detalles Bibliográficos
Autores principales: Li, Xu, Liang, Meng, Jiang, Jianxin, He, Ruizhi, Wang, Min, Guo, Xingjun, Shen, Ming, Qin, Renyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097472/
https://www.ncbi.nlm.nih.gov/pubmed/30123077
http://dx.doi.org/10.7150/ijbs.26776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097472/
https://www.ncbi.nlm.nih.gov/pubmed/30123077
http://dx.doi.org/10.7150/ijbs.26776

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