Simultaneously targeting DNA damage repair pathway and mTORC1/2 results in small cell lung cancer growth arrest via ER stress-induced apoptosis

Purpose: Small cell lung cancer (SCLC) is highly lethal with no effective therapy. Wee1 kinase inhibitor AZD1775 (MK-1775) and mTOR kinase inhibitor MLN0128 (TAK228) are in clinical trials for relapsed SCLC and recurrent lung cancer, respectively. However, there is no preclinical data combining thes...

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Detalles Bibliográficos
Autores principales: Fang, Bin, Kannan, Aarthi, Guo, Tao, Gao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097473/
https://www.ncbi.nlm.nih.gov/pubmed/30123071
http://dx.doi.org/10.7150/ijbs.25488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097473/
https://www.ncbi.nlm.nih.gov/pubmed/30123071
http://dx.doi.org/10.7150/ijbs.25488

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