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Two-step mechanism and step-arrest mutants of Runella slithyformis NAD(+)-dependent tRNA 2′-phosphotransferase Tpt1
Tpt1 catalyzes the transfer of an internal 2′-monophosphate moiety (2′-PO(4)) from a “branched” 2′-PO(4) RNA splice junction to NAD(+) to form a “clean” 2′-OH, 3′-5′ phosphodiester junction, ADP-ribose 1″-2″ cyclic phosphate, and nicotinamide. First discovered as an essential component of the Saccha...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097658/ https://www.ncbi.nlm.nih.gov/pubmed/29884622 http://dx.doi.org/10.1261/rna.067165.118 |