Cargando…
An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys
During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes. We studied IR mechanisms in the SF3B1 splicing factor gene, which expresses ∼50% of its transcripts in late erythrobla...
Autores principales: | Parra, Marilyn, Booth, Ben W., Weiszmann, Richard, Yee, Brian, Yeo, Gene W., Brown, James B., Celniker, Susan E., Conboy, John G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097662/ https://www.ncbi.nlm.nih.gov/pubmed/29959282 http://dx.doi.org/10.1261/rna.066951.118 |
Ejemplares similares
-
Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts
por: Parra, Marilyn, et al.
Publicado: (2020) -
A Deep Exon Cryptic Splice Site Promotes Aberrant Intron Retention in a Von Willebrand Disease Patient
por: Conboy, John G.
Publicado: (2021) -
Biased exon/intron distribution of cryptic and de novo 3′ splice sites
por: Královičová, Jana, et al.
Publicado: (2005) -
Intronic L1 Retrotransposons and Nested Genes Cause Transcriptional Interference by Inducing Intron Retention, Exonization and Cryptic Polyadenylation
por: Kaer, Kristel, et al.
Publicado: (2011) -
Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2
por: Yoshimoto, Satomi, et al.
Publicado: (2016)