Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

Translational efficiency correlates with longevity, yet its role in lifespan determination remains unclear. Using ribosome profiling, translation efficiency is globally reduced during replicative aging in budding yeast by at least two mechanisms: Firstly, Ssd1 is induced during aging, sequestering m...

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Detalles Bibliográficos
Autores principales: Hu, Zheng, Xia, Bo, Postnikoff, Spike DL, Shen, Zih-Jie, Tomoiaga, Alin S, Harkness, Troy A, Seol, Ja Hwan, Li, Wei, Chen, Kaifu, Tyler, Jessica K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097839/
https://www.ncbi.nlm.nih.gov/pubmed/30117416
http://dx.doi.org/10.7554/eLife.35551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097839/
https://www.ncbi.nlm.nih.gov/pubmed/30117416
http://dx.doi.org/10.7554/eLife.35551

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