Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes

Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Se-Hyung, Byeon, Ji-Young, Kim, Young-Hoon, Lee, Choong-Min, Lee, Yun Jeong, Jang, Choon-Gon, Lee, Seok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098032/
https://www.ncbi.nlm.nih.gov/pubmed/30120390
http://dx.doi.org/10.1038/s41598-018-30841-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098032/
https://www.ncbi.nlm.nih.gov/pubmed/30120390
http://dx.doi.org/10.1038/s41598-018-30841-8

Ejemplares similares