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Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes

Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Cl...

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Detalles Bibliográficos
Autores principales:	Kim, Se-Hyung, Byeon, Ji-Young, Kim, Young-Hoon, Lee, Choong-Min, Lee, Yun Jeong, Jang, Choon-Gon, Lee, Seok-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098032/ https://www.ncbi.nlm.nih.gov/pubmed/30120390 http://dx.doi.org/10.1038/s41598-018-30841-8

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