Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathem...

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Detalles Bibliográficos
Autores principales: Braun, Simon, Enculescu, Mihaela, Setty, Samarth T., Cortés-López, Mariela, de Almeida, Bernardo P., Sutandy, F. X.  Reymond, Schulz, Laura, Busch, Anke, Seiler, Markus, Ebersberger, Stefanie, Barbosa-Morais, Nuno L., Legewie, Stefan, König, Julian, Zarnack, Kathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098099/
https://www.ncbi.nlm.nih.gov/pubmed/30120239
http://dx.doi.org/10.1038/s41467-018-05748-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098099/
https://www.ncbi.nlm.nih.gov/pubmed/30120239
http://dx.doi.org/10.1038/s41467-018-05748-7

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