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Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathem...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098099/ https://www.ncbi.nlm.nih.gov/pubmed/30120239 http://dx.doi.org/10.1038/s41467-018-05748-7 |