Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

Food allergy poses a significant clinical and public health burden affecting 2–10% of infants. Using integrated DNA methylation and transcriptomic profiling, we found that polyclonal activation of naive CD4+ T cells through the T cell receptor results in poorer lymphoproliferative responses in child...

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Detalles Bibliográficos
Autores principales: Martino, David, Neeland, Melanie, Dang, Thanh, Cobb, Joanna, Ellis, Justine, Barnett, Alice, Tang, Mimi, Vuillermin, Peter, Allen, Katrina, Saffery, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098117/
https://www.ncbi.nlm.nih.gov/pubmed/30120223
http://dx.doi.org/10.1038/s41467-018-05608-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098117/
https://www.ncbi.nlm.nih.gov/pubmed/30120223
http://dx.doi.org/10.1038/s41467-018-05608-4

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