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Multicilin and activated E2f4 induce multiciliated cell differentiation in primary fibroblasts

Multiciliated cells (MCCs) are specialized epithelial cells that project hundreds of motile cilia. To form these cilia, MCCs differentiate by dramatically expanding centriole number, using assembly factors required for centriole duplication during the cell cycle and multiple, novel assembly sites, c...

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Detalles Bibliográficos
Autores principales: Kim, Seongjae, Ma, Lina, Shokhirev, Maxim N., Quigley, Ian, Kintner, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098136/
https://www.ncbi.nlm.nih.gov/pubmed/30120325
http://dx.doi.org/10.1038/s41598-018-30791-1