Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity

Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN). FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S...

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Detalles Bibliográficos
Autores principales: Fox, Nicholas G., Martelli, Alain, Nabhan, Joseph F., Janz, Jay, Borkowska, Oktawia, Bulawa, Christine, Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098246/
https://www.ncbi.nlm.nih.gov/pubmed/30031876
http://dx.doi.org/10.1016/j.biochi.2018.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098246/
https://www.ncbi.nlm.nih.gov/pubmed/30031876
http://dx.doi.org/10.1016/j.biochi.2018.07.012

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