Cargando…

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity

Human de novo iron-sulfur (Fe-S) assembly complex consists of cysteine desulfurase NFS1, accessory protein ISD11, acyl carrier protein ACP, scaffold protein ISCU, and allosteric activator frataxin (FXN). FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fox, Nicholas G., Martelli, Alain, Nabhan, Joseph F., Janz, Jay, Borkowska, Oktawia, Bulawa, Christine, Yue, Wyatt W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editions Scientifiques Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098246/ https://www.ncbi.nlm.nih.gov/pubmed/30031876 http://dx.doi.org/10.1016/j.biochi.2018.07.012

Ejemplares similares

ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin
por: Cai, Kai, et al.
Publicado: (2018)

Nfs1 cysteine desulfurase protein complexes and phosphorylation sites as assessed by mass spectrometry
por: Rocha, Agostinho G., et al.
Publicado: (2017)

Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly
por: Cai, Kai, et al.
Publicado: (2018)

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
por: Fujihara, Kenji M., et al.
Publicado: (2022)

Human Mitochondrial Chaperone (mtHSP70) and Cysteine Desulfurase (NFS1) Bind Preferentially to the Disordered Conformation, Whereas Co-chaperone (HSC20) Binds to the Structured Conformation of the Iron-Sulfur Cluster Scaffold Protein (ISCU)
por: Cai, Kai, et al.
Publicado: (2013)

Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex
por: Schmucker, Stéphane, et al.
Publicado: (2011)

The L-Cysteine Desulfurase NFS1 Is Localized in the Cytosol where it Provides the Sulfur for Molybdenum Cofactor Biosynthesis in Humans
por: Marelja, Zvonimir, et al.
Publicado: (2013)

Fumarase affects the deoxyribonucleic acid damage response by protecting the mitochondrial desulfurase Nfs1p from modification and inactivation
por: Yip, Joyce, et al.
Publicado: (2021)

During FeS cluster biogenesis, ferredoxin and frataxin use overlapping binding sites on yeast cysteine desulfurase Nfs1
por: Uzarska, Marta A., et al.
Publicado: (2022)

NFS illustrated
por: Callaghan, Brent
Publicado: (2000)

The role of zinc in the stability of the marginally stable IscU scaffold protein
por: Iannuzzi, Clara, et al.
Publicado: (2014)

Optimizing NFS performance: tuning and troubleshooting NFS on HP-UX systems
por: Olker, Dave
Publicado: (2003)

Managing NFS and NIS /
por: Stern, Hal
Publicado: (1992)

Managing NFS and NIS
por: Eisler, Mike, et al.
Publicado: (2001)

Differential expression of cysteine desulfurases in soybean
por: Heis, Marta D, et al.
Publicado: (2011)

Evolution of the NFS Filer Service
por: CANO, Eric, et al.
Publicado: (2015)

N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
por: Freibert, Sven-A., et al.
Publicado: (2021)

TCP/IP and NFS : internetworking in a UNIX environment /
por: Santifaller, Michael
Publicado: (1991)

Neutrons for Science (NFS) at SPIRAL-2
por: Ridikas, D, et al.
Publicado: (2005)

The Complex Energy Landscape of the Protein IscU
por: Bothe, Jameson R., et al.
Publicado: (2015)

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
por: Fox, Nicholas G., et al.
Publicado: (2019)

Ferredoxin Competes with Bacterial Frataxin in Binding to the Desulfurase IscS
por: Yan, Robert, et al.
Publicado: (2013)

The Multifaceted Bacterial Cysteine Desulfurases: From Metabolism to Pathogenesis
por: Das, Mayashree, et al.
Publicado: (2021)

Regulation of iron homeostasis by the p53-ISCU pathway
por: Funauchi, Yuki, et al.
Publicado: (2015)

Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom
por: Wan, Yu, et al.
Publicado: (2021)

ISCU interacts with NFU1, and ISCU[4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1
por: Cai, Kai, et al.
Publicado: (2020)

A novel cysteine desulfurase influencing organosulfur compounds in Lentinula edodes
por: Liu, Ying, et al.
Publicado: (2015)

Structural diversity of cysteine desulfurases involved in iron-sulfur cluster biosynthesis
por: Fujishiro, Takashi, et al.
Publicado: (2022)

Roles of conserved active site residues in the IscS cysteine desulfurase reaction
por: Pang, Yilin, et al.
Publicado: (2023)

Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System
por: Liu, Liqiong, et al.
Publicado: (2020)

Structural and Biochemical Characterization of Staphylococcus aureus Cysteine Desulfurase Complex SufSU
por: Hudspeth, Jesse D., et al.
Publicado: (2022)

A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy
por: Legati, Andrea, et al.
Publicado: (2017)

Identification of a Heat-Inducible Element of Cysteine Desulfurase Gene Promoter in Lentinula edodes
por: Huang, Zhicheng, et al.
Publicado: (2019)

The Cysteine Desulfurase IscS Is a Significant Target of 2-Aminoacrylate Damage in Pseudomonas aeruginosa
por: Fulton, Ronnie L., et al.
Publicado: (2022)

The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins
por: Yan, Robert, et al.
Publicado: (2018)

FDX2 and ISCU Gene Variations Lead to Rhabdomyolysis With Distinct Severity and Iron Regulation
por: Montealegre, Sebastian, et al.
Publicado: (2022)

Neutrons for Science (NFS) at SPIRAL-2 (Part II: pulsed neutron beam)
por: Ledoux, X, et al.
Publicado: (2005)

Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the iron–sulfur cluster assembly machinery
por: Böttinger, Lena, et al.
Publicado: (2018)

Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1
por: Ho, Thien-Hoang, et al.
Publicado: (2017)

The cytosolic Arabidopsis thaliana cysteine desulfurase ABA3 delivers sulfur to the sulfurtransferase STR18
por: Selles, Benjamin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qfamppdlqj3mkemjjbua2qc1jr